Connexin43 and the regulation of intercalated disc function
نویسندگان
چکیده
منابع مشابه
Interactions between ankyrin-G, Plakophilin-2, and Connexin43 at the cardiac intercalated disc.
RATIONALE The early description of the intercalated disc defined 3 structures, all of them involved in cell-cell communication: desmosomes, gap junctions, and adherens junctions. Current evidence demonstrates that molecules not involved in providing a physical continuum between cells also populate the intercalated disc. Key among them is the voltage-gated sodium channel complex. An important co...
متن کاملConnexin43 regulates sodium current; ankyrin-G modulates gap junctions: the intercalated disc exchanger.
Intercalated disc structures have conventionally been considered to be independent. Recent work shows that molecules initially thought of as belonging to one complex can actually affect another. Here, I focus on the cross-talk between connexin43 (Cx43, 'the gap junction protein') and the sodium channel complex and, conversely, on ankyrin-G (AnkG, a 'component of the sodium channel complex') and...
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Intercalated cells are kidney tubule epithelial cells with important roles in the regulation of acid-base homeostasis. However, in recent years the understanding of the function of the intercalated cell has become greatly enhanced and has shaped a new model for how the distal segments of the kidney tubule integrate salt and water reabsorption, potassium homeostasis, and acid-base status. These ...
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Connexin43 Hemichannel-Mediated Regulation of Connexin43
BACKGROUND Many signaling molecules and pathways that regulate gap junctions (GJs) protein expression and function are, in fact, also controlled by GJs. We, therefore, speculated an existence of the GJ channel-mediated self-regulation of GJs. Using a cell culture model in which nonjunctional connexin43 (Cx43) hemichannels were activated by cadmium (Cd(2+)), we tested this hypothesis. PRINCIPA...
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ژورنال
عنوان ژورنال: Heart Rhythm
سال: 2012
ISSN: 1547-5271
DOI: 10.1016/j.hrthm.2011.10.028